PhD Student in Translational Research
Every contribution counts – whether in research, administration or infrastructure. This is what makes our daily work so meaningful and exciting.
The Research Group "Tumorvirus-specific Vaccination Strategies" at the German Cancer Research Center (DKFZ) is seeking a
PhD Student in Translational Research
Reference number: 2024-0301- Heidelberg
- Full-time
- Research Group "Tumorvirus-specific Vaccination Strategies"
The aim of the PhD project is to explore the immune responses elicited in healthy volunteers following PANHPVAX vaccination.
Your Tasks
The N-terminal region of the human papillomavirus (HPV) L2 protein has been shown to contain epitopes able to induce the production of neutralizing and cross-neutralizing antibodies. Using bacterial thioredoxin as a scaffold, we managed to significantly enhance the immunogenicity of putative L2 neutralizing epitopes.In the past years, we extensively optimized the prophylactic vaccine antigen and also determined its safety in an animal model.
We now entered into a clinical development phase and are starting a phase I clinical trial (EudraCT No.: 2021-002584-22). This trial should demonstrate safety and immunogenicity. Our vaccine is based on a single molecule, is highly thermostable and more importantly, induces protective responses against all oncogenic HPV as well as a number of so called ‘low risk’ HPV.Therefore, the vaccine has the potential to provide protection against HPV also in regions where the current HPV vaccines cannot be distributed, which applies to about two thirds of all countries.
This position offers exceptional development opportunities in the rapidly evolving field of translational medicine, with a focus on the design, execution, and oversight of pre-clinical studies. The DKFZ provides an outstanding research environment, with access to state-of-the-art laboratory facilities and comprehensive material cost funding.
Your Profile
We are seeking highly motivated candidates with a master's degree in biochemistry, biology, or molecular medicine, and a strong background in immunology and/or molecular biology. The ideal candidate should be a team player with the ability to conduct independent research rigorously, while also embracing the collaborative spirit of our research group.
We Offer- Excellent framework conditions: state-of-the-art equipment and opportunities for international networking at the highest level
- Access to international research networks
- Doctoral salary with the usual social benefits
- 30 days of vacation per year
- Flexible working hours
- Possibility of part-time work
- Family-friendly working environment
- Sustainable travel to work: subsidized Germany job ticket
- Unleash your full potential: targeted training and mentoring through the DKFZ International PhD Program and DKFZ Career Service
- Our Corporate Health Management Program offers a holistic approach to your well-being
Phone: +49 6221 42-4628
The position is initially limited to 3 years.
Are you interested?
Then become part of the DKFZ and join us in contributing to a life without cancer!
Apply now
We are convinced that an innovative research and working environment thrives on the diversity of its employees. Therefore, we welcome applications from talented people, regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical ability, religion and age.People with severe disabilities are given preference if they have the same aptitude.
Notice: We are subject to the regulations of the Infection Protection Act (IfSG). Therefore, all our employees must provide proof of immunity against measles.
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