Deutsches Krebsforschungszentrum - Senior Postdoc for the Division of Personalized Immunotherapies

Every contribution counts – whether in research, administration, or infrastructure. This is what makes our daily work so meaningful and exciting.

The goal of the partnership is to develop effective immunotherapies and to identify novel biomarkers for assessing the effectiveness of treatment.

To strengthen the HI-TRON team in Mainz, we are seeking a skilled and motivated

Senior Postdoc for the Division of Personalized Immunotherapies

• Mainz
• Fulltime
• HI-TRON Mainz – Personalized Immunotherapies

The successful candidate will be instrumental in advancing fundamental knowledge and creating novel technologies to enable cell-specific biomolecule delivery.

• Lead the development and optimization of LNP formulation for cell-specific biomolecule delivery, including high-throughput screening of lipid compositions and formulation parameters
• Develop and apply methods for LNP purification and characterization
• Apply in vitro and in vivo models to assess biodistribution, efficiency, toxicity, and cell-specific LNP uptake
• Lead the development of LNP targeting strategies using ligand conjugation, peptides, or antibodies for cell / tissue-specific delivery
• Present research findings internally and externally (national and international conferences) and publish in peer-reviewed scientific journals
• Identify new research directions, develop grant proposals, and contribute to securing external funding

• Master's degree and PhD in pharmaceutical sciences, chemistry, bio- or chemical engineering, or related fields
• Extensive experience in LNP formulation methods, including hands-on experience with microfluidic devices, and targeted delivery strategies, including bioconjugation techniques
• Deep knowledge in nanoparticle purification (e.g., size-exclusion chromatography, ultracentrifugation, and dialysis), and characterization (e.g., dynamic light scattering, and Cryo-EM)
• Strong background in relevant in vitro and in vivo models and approaches for evaluating key parameters of nanoparticles, such as efficacy, biodistribution, and toxicity
• Proven publication record in high-impact journals related to biological therapeutics and nanomedicine
• Meticulous, quality-focused, and able to work independently while consistently meeting deadlines with a high degree of accuracy and efficiency
• Strong written and oral communication skills in English with effective interpersonal skills that foster teamwork and collaboration

• Excellent framework conditions: state-of-the-art equipment and opportunities for international networking at the highest level
• Remuneration according to TV-L incl. occupational pension plan and capital-forming payments
• 30 days of vacation per year
• Flexible working hours
• Possibility of part-time work
• Family-friendly working environment
• Sustainable travel to work: subsidized Germany job ticket
• Our Corporate Health Management Program offers a holistic approach to your well-being
• Develop your full potential: access to the DKFZ International Postdoc Program and DKFZ Career Service with targeted offers for your personal development to further develop your talents

Telefon: +49 6131 179816

The position is limited to 3 years with the possibility of prolongation.

Are you interested?

Then become part of the DKFZ and join us in contributing to a life without cancer!

Apply now

People with severe disabilities are given preference if they have the same aptitude.

Notice: We are subject to the regulations of the Infection Protection Act (IfSG). Therefore, all our employees must provide proof of immunity against measles.

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Deutsches Krebsforschungszentrum | Im Neuenheimer Feld 280 | 69120 Heidelberg | www.dkfz.de