PhD Student in Lipid Droplet Biology in Cancer
Deutsches Krebsforschungszentrum (DKFZ) Heidelberg
Research for a life without cancer“ is our mission at the German Cancer Research Center. We investigate how cancer develops, identify cancer risk factors and look for new cancer prevention strategies. We develop new methods with which tumors can be diagnosed more precisely and cancer patients can be treated more successfully. Every contribution counts – whether in research, administration or infrastructure. This is what makes our daily work so meaningful and exciting. The Division of Tumor Metabolism and Microenvironment is seeking for the next possible date a PhD Student in Lipid Droplet Biology in Cancer Reference number:
We have previously demonstrated a link between activation of the PI3-kinase/Akt/mTORC1 signalling axis and the control of lipid biosynthesis in cancer cells.
The induction of lipid synthesis is crucial for the growth of cancer cells.
These are combined with cell culture systems that recreate the environmental conditions of the tumour microenvironment (3D culture, hypoxia, physiological media).
We also apply direct in vivo screening approaches using transposon-based gene transfer.
Then become part of the DKFZ and join us in contributing to a life without cancer!
Apply now We are convinced that an innovative research and working environment thrives on the diversity of its employees.
Therefore, we welcome applications from talented people, regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical ability, religion and age.
- 2024-0373
- Heidelberg
- Full-time * Tumor Metabolism and Microenvironment Altered metabolism is a hallmark of cancer and metabolic reprogramming in cancer supports the synthesis of macromolecules for cell growth and proliferation.
However, it also generates selective vulnerabilities that can be exploited for cancer therapy.
Our group is interested in understanding how oncogenic signalling networks induce metabolic reprogramming in cancer.We have previously demonstrated a link between activation of the PI3-kinase/Akt/mTORC1 signalling axis and the control of lipid biosynthesis in cancer cells.
The induction of lipid synthesis is crucial for the growth of cancer cells.
More recently, it is emerging that altered lipid metabolism contributes to multiple cancer phenotypes, including cell survival, cell migration, cell-cell communication and immune interactions (Röhrig and Schulze, Nature Reviews Cancer, 2016).
To identify metabolic genes that are particularly important for the growth and survival of cancer cells, we apply functional genomic screening technologies (RNAi, CRISPR/Cas9).These are combined with cell culture systems that recreate the environmental conditions of the tumour microenvironment (3D culture, hypoxia, physiological media).
We also apply direct in vivo screening approaches using transposon-based gene transfer.
In addition, we perform targeted metabolomics and metabolic flux analysis with stable isotope labelled compounds to investigate the metabolic wiring in cancer cells.
Your Tasks- Analysis of lipid droplet dynamics and exploration of the contribution of fatty acid channeling to tumorigenesis and stress resistance in liver cancer
- Analysis of the role of oncogenic drivers on lipid droplet heterogeneity in liver cancer cells
- Investigation of lipid droplet dynamics in liver cancer
- Contribution to the training and teaching activities of the division
- Preparation of scientific presentations and publications Your Profile
- Master's degree in biology, biochemistry or related disciplines
- Previous experience in molecular biology and biochemical techniques
- Good knowledge of biochemistry
- FELASA certificate is an advantage
- Excellent command of written and oral English with proof of language proficiency (not required for applicants from EU or North America) We Offer
- Excellent framework conditions: state-of-the-art equipment and opportunities for international networking at the highest level
- Access to international research networks
- Remuneration according to TV-L incl.
- 30 days of vacation per year
- Flexible working hours
- Possibility of part-time work
- Family-friendly working environment
- Sustainable travel to work: subsidized Germany job ticket
- Unleash your full potential: targeted training and mentoring through the DKFZ International PhD Program and DKFZ Career Service
- Our Corporate Health Management Program offers a holistic approach to your well-being Contact: Prof.
Dr. Almut Schulze Telefon: +49 6221 42-3423 The position is initially limited to 3 years.
Are you interested?Then become part of the DKFZ and join us in contributing to a life without cancer!
Apply now We are convinced that an innovative research and working environment thrives on the diversity of its employees.
Therefore, we welcome applications from talented people, regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical ability, religion and age.
People with severe disabilities are given preference if they have the same aptitude.
Notice: We are subject to the regulations of the Infection Protection Act (IfSG).
Therefore, all our employees must provide proof of immunity against measles.Share this job!
Deutsches Krebsforschungszentrum | Im Neuenheimer Feld 280 | 69120 Heidelberg | www.dkfz.de
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